Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction

Año de publicación

2004

UUID

915b1f70-7413-428c-89a9-bbf127975ceb

Resumen

There is growing evidence that DNA damage caused by mutagens found in tobacco smoke may contribute to the development of coronary heart disease (CHD). In order to bind to DNA many mutagens require metabolic activation by cytochrome P450 (CYP) 1A1 or CYP1A2. The objective of this study was to determine the effects of CYP1A1 and CYP1A2 genotypes on risk of myocardial infarction (MI) and whether smoking interacts with genotype to modify risk.

Publicador

Journal of Medical Genetics, Volumen 41, no. 10

Enlace del origen de la publicación

Documentación restringida

Sí

Tipo de publicación

Article

Descriptores

• INFARTO DE MIOCARDIO
• TABACO
• ENEFERMEDADES CARDIOVASCULARES
• ENFERMEDADES CORONARIAS